Disinfecting cleansing pad



Nov. 8, 1966 J. w. DECKER E AL 3,

DISINFECTING CLEANSING PAD Filed Oct. 6, 1964 United States Patent3,283,357 DISINFECTING CLEANSING PAD John W. Decker, Scuthfield, andCharles G. Koella,

Rochester, Mich, assignors to Michigan Tool Company, Detroit, Mich, acorporation of Delaware Filed Oct. 6, 1964, Ser. No. 401,877 4 Claims.(Cl. --506) The present invention broadly relates to a disinfectingcleaning aid, and more particularly to a novel disposable pad at least aportion of which is impregnated with a germicidal and cleaning agent.More specifically, the present invention is directed to 'a noveldisposable pad or sponge which incorporates a substantially drywatersoluble impregnant consisting of a germicidal quaternary ammoniumcompound and a controlled proportion of and amphoteric detergent whichare activated by simply moistening the pad or sponge immediately priorto use.

Various disinfecting and cleaning formulations and techniques haveheretofore been in use or proposed for use in connection with generalmedicinal, industrial, agricultural, institutional, and residentialdisinfecting usus. The general difiiculty and inconvenience necessitatedwith the use of such formulations in addition to the care required toassure proper disinfecting of the surfaces cleaned has somewhatdetracted from -a more widespread use and acceptance of such chemicalgermicidal cleaning formulations. The high antimicrobial :av-tivities ofquaternary ammonium compounds are well recognized in the art, but theincompatability thereof with many cleaning and detergent materials hasoccasioned a limitation on their more widespread use in formulationsembodying a combined disinfecting and cleaning action.

In order to overcome the foregoing problems and disadvantages inherentin disinfecting cleaning compositions heretofore known, a scrubbing pad,in accordance with the present invention, has been devised whichincorporates on at least a portion of the surfaces thereof an impregnantconsisting of germicidal quaternary ammonium compounds in combinationwith controlled proportions of amphoteric and nonionic detergents which,upon moistening immediately prior to use, are effective to provide ahigh degree of antimicrobial and cleaning action on the surfacesscrubbed therewith. The disinfecting cleansing pad comprising thepresent invention incorporates a premeasured amount of germicide anddetergent which are present in a substantially dry form and enablessimple use thereof without encountering any leakage, drippage or wastefrequently associated with the use of various detergent and germicidalformulations of the types heretofore known. Additionally, the mechanicalabrasion of the sponge or pad incorporating the impregnant with thesurface being cleansed thereby assures an intimate cont-act and removalof dirt and a substantially complete destruction of any microbialcontamination on the surface. The disinfecting cleansing pad comprisingthe present invention, in view of its improved biocidal activity andcleaning action in combination with the extreme convenience in its use,provides for distinct advantages over the various germicidal cleaningformulations heretofore known.

It is accordingly a principal object of the present invention to providea novel disposable disinfecting cleansing pad which can be storedindefinitely and which incorporates a premeasured quantity of agermicidal agent and a cleansing agent that are activated simply bymoistening the pad immediately prior to use.

"ice

Another object of the present invention is to provide novel disinfectingcleansing pad or sponge which is of low cost, enabling it to be disposedof after one use and avoiding thereby any possibility of microbialcontamination with subsequent SlllffiCfiS coming in contact therewith.

Still another object of the present invention is to provide a noveldisposable disinfecting cleansing pad which is particularly effective inconnection with the cleansing and disinfecting of human and animal skintissues as is required in general medical practice or the like,providing for greater convenience than has heretofore been possible.

A further object of the present invention is to provide a noveldisposable disinfecting cleansing pad or sponge which possessesexcellent biocidal and cleaning activities, is simple to prepare,extremely convenient in use, and is of low cost, enabling it to bedisposed of after a single use.

The foregoing and other objects and advantages of the present inventionare achieved by providing a porouus absorbent pad or sponge at least aportion of which is coated with a germicidal quaternary ammoniumcompound in combination with an amphoteric detergent which mayadditionally include a nonionic detergent in controlled proportions suchthat the total detergent present ranges from at least about 50 parts upto about parts per part of the germicidal quaternary ammonium compoundpresent. The total quantity of coating on the pad or sponge will varyconsistent with its intended end use. Ordinarily the quantity of thegermicidal quaternary ammonium compound is controlled to provide atleast about a 50 parts per million (p.p.m.) concentration thereof in thewater employed for moistening the sponge during its use.

Other objects and advantages of the present invention will becomeapparent on the reading of the following description taken inconjunction with the accompanying drawing, wherein:

FIGURE 1 is a perspective view of a typical disposable sponge made of acellular plastic material, and

FIGURE 2 is a fragmentary transverse sectional view through the cellularsponge, illustrating a coating of the combined germicidal and cleaningcomposition on a portion of the surfaces thereon.

For the purposes of the present invention, the disposable pad or sponge10 may comprise any suitable fibrous or cellular structure comprised ofa material which is compatible with and chemically resistant to thegermicidal and cleaning agent coated on at least a portion of thesurface 12 thereof. Pads comprised of fibrous materials includingsynthetic fibers such as acetate, polyester, nylon, or the like, as wellas natural fibers such as cotton, wool, etc., can be satisfactorilyemployed for this purpose. Preferably, the pad material is comprised ofa resilient cellular structure such as provided by a natural spongematerial, latex foam, or various resilient synthetic foam materials, ofwhich a polyurethane foam pad is preferred. When cellular pad materialsare employed, it is preferred that the cells thereof are closed to avoida significant penetration of the germicidal cleaning agent into theinterior of the pad, causing entrapment thereof within the intersticesof the pad and retarding its availbility at time of use. Particularlysatisfactory results have been obtained by employing flexiblepolyurethane foam pads of a close cell structure, the outer surfaces ofwhich have been coated and/ or impregnated with the is as follows:

germicidal cleaning agent of a composition as hereinafter provided.

The germicidal agent employed in the disinfecting and cleaning agentcomprises a quaternary ammonium com- Quaternary ammonium compoundscorresponding to the foregoing structural formula are 1 typified by twocommercially available classes, one .of which is characterized by astructure in which R and R are alkyl radicals containing 1 to 4 carbonatoms while R is an aryl or arakyl radical of which the alkylsubstituent may contain from 0 to 4 carbon atoms and R is an aliphatichydrocarbon radical having a carbon 1 content ranging from C up to aboutC This class may be generally described as an alkyl di-R benzyl ammoniumhalide compound, of which dimethyl benzyl ammonium chloride and dimethylethylbenzyl ammonium chloride are typical. A second commerciallyavailable and useful. class within the general formula as hereinaboveset forth includes quaternary ammonium compounds in which R 1 and R arealkyl radicals containing 1 to 4 carbon atoms -while R and R arelong-chain aliphatic hydrocarbon radicals conventionally derived fromfatty acids containing va carbon content ranging from about C up toabout C A satisfactory material within the general description of thissecond class comprises dicoco dimethyl ammonium chloride in which theradicals R and R are I derived from the fatty acids of coconut oil.

In each of the aforementioned two typical quaternary ammonium compoundclasses, the long-chain aliphatic hydrocarbon radicals incorporatedthereon may range as low as C to as high as C However, it has been foundthat, when the carbon content of the long-chain alkyl .radicals is lessthan about C only. minimal antimicrobial activity is provided, whilesimilar results are obtained when the carbon content of the alkylradical is greaterthan C Alkyl radicals, on the other hand, havingcarbon contents of C C and C when combined in quaternary ammoniumcompounds of the aforementioned types, posjsess the most effectiveantimicrobial activity, while the C alkyl derivative has a lower butalso appreciable germicidal activity. conventionally, the quaternaryammonium compounds employed may be mixtures of compounds within ductionin the surface and interfacial tension of water, enhancing thepenetration of the germicidal cleaning formulation into the surfacesbeing cleansed, thereby assuring substantially complete killing of allharmful bacteria.

In addition to the quaternary ammonium compound,

the germicidal cleansing agent impregnated in the cleansing pad furtherincludes an amphoteric detergent or surface-active agent comprising thecondensation product of acrylic monomers and fatty primary meansproducing monoand di-propionate compounds which are characterized inthat they contain both carboxyl and amino functionality in theirmolecular structure. The general formula of a mono-propionate salt whichmay conventionally be designated as an n-fatty beta aminopropionateRHNCH CH COOX A di-propionate compound conventionally designated as 4,an n-fatty beta iminodipropionate can be graphically repre sented by thefollowing formula:

RN(CH CH COOX) 2 In the structural formulas of the amphoteric detergentas hereinabove set forth, R comprises an aliphatic hydrocarbon radicalcontaining about 8 to 22 carbon atoms such as derived from long-chainfatty acids, of which lauric acid and myristic acid are typical. Theradical X may comprise any salt-forming cation or hydrogen such as, forexample, any of the alkali metals including sodium or potassium. It isimportant, in order to achieve the benefits of the present invention,that the germicidal cleaning agent employed for impregnating the padinclude an amphoteric detergent of the aforementioned type, eithersingly or in combination with suitable nonionic detergents of the typesubsequently to be described wherein the amparts detergent per partquaternary ammonium compound.

up to about 25 parts detergent per part quaternary am monium compound,and preferably from about 7 parts to about 10 parts detergent per partquaternary ammonium compound. When the detergent is employed in amountsless than about 4 parts detergent per part quaternary ammonium compound,insufficient cleansing action is pro vided by the cleansing pad, whereasamounts of detergent in excess of about 25 parts per part quaternaryammonium compound tend to cause skin irritation due to the leaching ofskin fats during the use of the cleansing pad and, accordingly, areundesirable. Particularly satis-' factory results have been achievedwhen the ratio of total detergent present is controlled within about 7parts to about 10 parts per part of quaternary ammonium compoundpresent.

As hereinbefore mentioned, suitable nonionic detergents can besatisfactorily employed as a substitute for a portion of the amphotericdetergent, provided that the amphoteric detergent comprises at leastabout 20% of the total detergent present. The inclusion of at. least 20%of the amphoteric detergent based on the total detergent is essential inorder to achieve a synergistic antimicrobial action of the resultantgermicidal cleaning.

formulationand to provide a cleaning agent which'is stable andcompatible without encountering an adverse reduction in its germicidalactivity. The suitable nonionic detergents which can be satisfactorilyemployed may be either of low, intermediate, or high foamingcharacteristics in accordance with the specific chemical structure ofthe molecule and consistent with the desired end use of the cleansingpad. Typical nonionic detergents of the types which can besatisfactorily employed may be of & either one or mixtures, of thegeneral classes as set forth below:

TABLE 1 Fatty alkanolamides Fatty alcohol ethylene oxide Polyoxyethylenefatty acid ester Polyethylene glycol oleate Polyoxyethylene alkyl phenolEthanolamide fatty acid condensate Polyoxyethylene propylene glycolmonostearate Iso-octyl phenoxy polyoxyethylene ethanol Nonylphenolpolyglycol ether alcohol Alkylphenol ethylene oxide condensate Alkylaryl polyether alcohol Aromatic polyglycol ether condensate Polyethyleneglycol esters of fatty acids Aliphatic polyoxyethylene ether alcoholAlkoxy polyoxyethylene ethanol Polyoxyethylene ester Alkylarylpolyethylene glycol ether Alkyl aryl ether Isooctyl phenyl polyethoxyethanol Nonyl phenoxy polyoxyethylene ethanol In addition to thequaternary ammonium germicidal compound and the detergent component, theimpregnant for the disinfecting cleansing pad may also include suitablehumectants or emollients such as polyethylene glycol, sorbitol,glycerine or the like in amounts sufiicient to enhance the soothing ofthe skin tissues against which the disinfecting cleasning pad is appliedduring use. The quantity of emollient employed will vary depending onthe particular size of the disinfecting pad, as well as the nature ofthe skin tissues to be contacted therewith and the quantity and/ orconcentration of the germicidal cleansing impregnant contained in thepad. conventionally, the emollient can be employed in amounts up toabout 5 parts per part of the quaternary ammonium compound present,depending on the particular characteristics of the pad employed. Amountsgenerally in excess of about 5 parts emollient per part quaternaryammonium compound detract from the seemingly dry characteristics of thedisinfecting cleansing pad prior to contact with water before use.

The total quantity of the quarternary ammonium compound and detergentimpregnated in the porous pad will also vary depending on the specificsize of the pad, the contemplated dilution of the impregnant with waterduring use, and the germicidal cleasning action desired. Conventionally,concentrations of the quaternary ammonium compound are employed suchthat the resultant wash solution when employed in the anticipated amountwill include a concentration in the aqueous solution formed of at leastabout 400 p.p.m. of the quartet-nary ammonium germicidal constituent. Ithas been found that concentrations of the quaternary ammonium compoundas low as about 50 p.p.m. in the resultant aqueous wash solution withwhich the cleansing pad is moistened provides sanitizing of the skintissues exposed to contact with the cleaning solution and cleansing pad.Generally, however, it is preferred to incorporate suflicient impregnantin the cleansing pad to provide a concentration of the quaternaryammonium compound in the aqueous cleaning solution of from at leastabout 200 ppm. up to about 1000 p.p.m., assuring a substantiallycomplete killing of all harmful bacteria. Excessive impregnation of theporous disinfecting pad is to be avoided since inadequate quantities ofwater employed for moistening the sponge or pad, resulting inconcentrations of the quaternary ammonium compound substantially aboveabout 1000 p.p.m., have been found to cause some human skin irritationwith certain individuals. In view of the foregoing, and further in viewof the fact that concentrations above about 1000 p.p.m. of thequaternary ammonium compound do not provide any appreciable germicidalbenefits above that attained by concentrations in the range of about 400p.p.m. to about 1000 p.p.m. the use of excessive quantities ofimpregnated constitutes an uneconomical utilization of the germicidalcleansing agent.

It can generally be anticipated that approximately one liter of water isemployed for moistening the disinfecting cleansing pad prior and duringuse for cleansing and disinfecting skin tissues. Under such conditions,it has been found that, when employing a porous pad comprised of aclosed-cell polyurethane foam of a size 3 inches by 3 inches by A inchthick, satisfactory antiseptic and cleansing characteristics areachieved by utilizing a germicidal cleansing agent distributedsubstantially uniformly over the outer surfaces of the pad in an amountof 600 milligrams (mg) of the quaternary ammonium compound and about10,800 mg. total detergent. Excellent germicidal cleansing action isachieved by a similar pad impregnated with a disinfecting cleaning agentcomprising 800 mg. quaternary ammonium compound and 10,600 mg. of totaldetergent. As a surgioal scrub, a cellular polyurethane sponge of theaforementioned size and configuration has provided exceptionallysatisfactory results when impregnated with a germicidal cleansingcomposition consisting of 2500 mg. quaternary ammonium compound and10,100 mg. of total detergent. In each of the foregoing instances,approximately one liter of wash water was employed for moistening thesponge and for contacting the human skin tissues to be cleansed anddisinfected. It will be apparent from the foregoing that modificationsin the total impregnant present on the surfaces of the disinfectingcleansing -pad will vary consistent with the intended end use of the padand the contemplated dilution of the germicidal cleansing agent onbecoming dissolved in the wash water.

It is further contemplated within the scope of the present inventionthat the impregnant on at least a portion of the surfaces of the porouspad may also include, in addition to the quaternary ammonium compound,the detergent compound, and the emollient, a suitable buffering agentsuch as triethanolamine or potassium acid phosphate in an amountsuflicient to control the pH of the resultant wash solution at asubstantially neutral or slightly alkaline range. The inclusion of abuffering agent, however, does not constitute a necessary constituent tothe germicidal cleaning impregnant as herein disclosed. The impregnantmay also include, if desired, a suitable die or pigment or,alternatively, the pad itself can be provided with a distinct color tovisually apprise the user of the concentration of the impregnant inaccordance with a preselected color code.

The application and impregnation or coating of at least a portion of thesurfaces of a suitable porous pad or sponge can be conveniently achievedby forming a concentrated solution of the active constituent andthereafter applying it to the pad such as by means of spray coating,roller coating, dipping, floating the pad on a bath of the solution, orthe like.

The resultant coated or impregnated pad thereafter is dried to removethe water or solvent from the solution, leaving thereby a residuaryprecipitate of the active constituents on the surfaces of the pad. Theseprecipitated constituents are readily soluble in the subsequent washwater by simply immersing the sponge and placing it in rubbing contactwith the skin tissues to be cleansed. While an aqueous concentratedsolution of the germicidal cleansing formulation can be employed forimpregnating the pad, it is usually preferred to employ suitable organicsolvents such as alcohol, of which isopropyl alcohol constitutes apreferred material for admixture with a suitable quantity of water,thereby facilitating evaporation of the solvent at the completion of theimpregnating operation. By virtue of including a volatile solvent suchas isopropyl alcohol, for example, in the concentrate solution,relatively rapid and elficient drying at relatively low temperatures ofthe impregnated pad can be achieved such as by emplgoying recirculatingheated air, infrared heating, or the li e.

In order to further illustrate the novel disinfecting cleansing padcomprising the present invention, the following example is provided. Itwill be understood, however, that the example is provided forillustrative purposes and it is not intended to be limiting of the scopeof the invention as set forth in the subjoined claims.

Example 1 A series of surgical pads having a germicidal efliciency wereprepared, employing a flexible resilient cellular polyurethane foammaterial which was cut to sizes of 3 inches by 3 inches by A inch thick.The pads were impregnated with a concentrate of a germicidal cleaningformulation providing for a residuary precipitate of about 800 .mg. 1 ofthe quaternary ammonium compound and 10,600 mg. of a mixed amphotericand nonionic detergent. The specifific composition of the germicidalcleaning formulation 1 is set forth in Table 2.

TABLE 2 Constituent:

Germicidal agentnC dimethyl benzyl ammonium Amount, mg.

As will be noted in Table 2, the germicidal agent employed comprised amixture of the C C C and C alkyl quaternary ammonium salt of di-methylbenzyl amf monium chloride and di-methyl ethylbenzy-l ammonium 1chloride.

The detergent component employed comprised a blend of an amphotericsurface-active agent comprising 1 a mixture of n-lauryl and n-myristylbeta-aminopropionic acid and a nonionic detergent commercially availableas j Sterox-N-J in the proportions of about 88.9% by weight amphotericdetergent and 11J1% by weight of the nonionic deter-gent.

The ratio of the total detergent present jto the germicidal agentemployed was approximately 1 5.6:1 corresponding to 10,600 mg. detergentper 800 mg. .of the mixed quaternary ammonium germicidal compounds.

The precipitated germicidal cleaning formulation of the composition asspecified in Table 2 was applied to the 1 surfaces of the cellular padmaterial in the form of a fine I spray employing a concentrate solutionof the constituents thereafter evaporated by exposing the wetimpregnated in isopropyl alcohol as a solvent. The isopropyl alcohol andresiduary water in the concentrated solution was sponge to heatedrecirculating air. The resultant dried "sponge or pad incorporating thesubstantially dry and water soluble precipitate of the germicidalcleaning comings.

position is illustrated in FIGURES l and 2 of the draw- As will be notedin FIGURE 1, the cellular pad material indicated at 10, consisting of aflexible and pliable polyurethane foam of a closed cell structure, isprovided with a substantially dry water-soluble coating indicated at 12in FIGURE 2 over substantially all of the 'exterior surfaces thereof andthe exposed cell walls such that, on exposure of the pad to waterimmediately prior to use, a rapid solution of the precipitated materialis effected, forming an aqueous disinfecting cleaning solution forcleansing and disinfecting human skin tissues or the like.

In order to evaluate the germicidal activity of the disinfectingcleansing pad, a series of the pads, as prepared,

were subjected to tests for a determination of their germicidal activityin accordance with the A.O.A.C. method, th Edition, employing atween-lecithin neutralizer. In

accordance with the test procedure, two microbial organ- Si isms wereemployed, namely Staphyloccus aureus and Escherichia coli which weresubjected to a milliliter sample of an aqueous solution in which each ofthe pads had been soaked for a period of 10 minutes. The quantity ofwater in which the pads were soaked was varied, providing thereby avariation in the net concentration of the germicidal cleansing agentdissolved inthe tap water. The results of these tests are tabulated inTable 3 in which the percent kill is provided of the two microorganismsat exposure times of 30 seconds and 60 seconds respectively, to 100milliliter samples of the tap solution in which the pads were soaked:

The test data as set forth in Table 3 comprises the average of twoseparate tests conducted at each of the dilution ratios and at each ofthe two exposure times of 30 seconds and 60 seconds, respectively, foreach of the two organisms. As will be noted, a substantially completekilling of the organisms was achieved even when concentrations of thewash water employed were as high as two liters in the case of the testson the Staphylococcus aureus and one liter on Escherichia 0011'. Thesetest data clearly establish the effectiveness in the germicidal andcleansing action of the disinfecting cleansing pads comprising thepresent invention.

While it will be apparent that the preferred embodiments of theinvention disclosed are well calculated to fulfill the objects abovestated, it will be appreciated that the invention is susceptible tomodification, variation and, I

change without departing from the proper scope or fair meaning of thesubjoined claims. I

What is claimed is:

1. A disinfecting cleansing pad comprising a pliable pad of asubstantially closed cellular foam of a compatible material, a coatingof a water-soluble germicidal cleaning agent on at least a portion ofthe exterior surfaces of said pad and consisting essentially of agermicidal quaternary ammonium compound and a detergent present in anamount of from about.4 parts to about 25 parts per part said quaternaryammonium compound, said detergent consisting essentially of anamphoteric detergent selected 'from the group consisting of n-fattybeta-aminopropionic acid, n-fatty beta iminodipropionic acid, as well assalts and mixtures thereof.

2. .A disinfecting cleansing pad comprising a pliable pad of asubstantially closed cell cellular foam of a compatible material, acoating of a water-soluble germicidal cleaning agent on at least aportion of the exterior surfaces of said pad and consisting essentiallyof a germicidal quaternary ammonium compound and a detergent present inan amount of from about 4 parts to about 25 parts per part saidquaternary ammonium compound, said de-, tergent consisting essentiallyof an amphoteric detergent selected from the group consisting of n-fattybeta-a-mino l propionic acid, n-fatty beta iminodipropionic acid, aswell as salts and mixtures thereof, and an emollient selected from thegroup consisting of polyethylene glycol, corbitol, glycerine, andmixtures thereof present in an amount up to about 5 parts emollient perpart said quaternary am- *rnonium compound.

3. A disinfecting cleansing pad comprising a resilient substantiallyclosed-type polyurethane foam pad, a coating of a water solublegermicidal cleaning agent on at least a portion of the exterior surfaceof said pad and consisting essentially of a germicidal quaternaryammonium compound and a detergent, said detergent present in an amountof from about 4 parts to about 25 parts of said quaternary ammoniumcompound, said detergent consisting essentially of a mixture of anampho-teric detergent selected from the group consisting of n-fatty betaam-inopropionic acid, n-fatty beta iminod-ipropionic acid, as well assalts and mixtures thereof, and a nonionic detergent wherein saidamphoteric detergent comprises at least 20% by weight of the total saiddetergent present.

4. A disinfecting cleansing pad comprising a resilient substantiallyclosed cell-type polyurethane cellular pad, a coating of a water solublegermicidal cleaning agent on at least a portion of the exterior surfaceof said pad and consisting essentially of a germicidal quaternaryammonium compound and a detergent, said detergent present in an amountof from about 4 parts to about 25 parts of said quaternary ammoniumcompound, said detergent consisting essentially of a mixture of anamphoteric detergent selected from the group consisting of n-fatty betaaminopropiona-te acid, n-fatty bet-a i-minodipropion-ic acid, as well assalts and mixtures thereof, and a nonionic detergent wherein saidamphoteric detergent comprises at least 20% by weight of the total saiddetergent present, and an emollient selected from the group consistingof polyethylene glycol, sorbito-l, glycerine, and mixtures thereofpresent in an amount up to about 5 parts emollient per part saidquaternary ammonium compound.

References Cited by the Examiner UNITED STATES PATENTS 2,468,012 4/1949Isbell.

2,820,043 1/1958 Rainey et a1.

2,999,265 9/1961 Duane et a1. l5506 3,088,158 5/1963 Boyle et a1. 155063,115,425 112/ 19-63 Zmoda 2529'1 X 3,138,533 6/1964 Heim et al 252-91 XCHARLES A. WILLMUTH, Primary Examiner.

R. L. B'LEU'IGE, Assistant Examiner.

1. A DISINFECTING CLEANING PAD COMPRISING A PLIABLE PAD OF ASUBSTANTIALLY CLOSED CELLULAR FOAM OF A COMPATIBLE MATERIAL, A COATINGOF A WATER-SOLUBLE GERMICIDAL CLEANING AGENT ON AT LEAST A PORTION OFTHE EXTERIOR SURFACES OF SAID PAD AND CONSISTING ESSENTIALLY OF AGERMICIDAL QUATERNARY AMMONIUM COMPOUND AND A DETERGENT PRESENT IN ANAMOUNT OF FROM ABOUT 4 PARTS TO ABOUT 25 PARTS PER PART SAID QUATERNARYAMMONIUM COMPOUND, SAID DETERGENT CONSISTING ESSENTIALLY OF ANAMPHOTERIC DETERGENT SELECTED FROM THE GROUP CONSISTING OF N-FATTYBATA-AMINOPROPIONIC ACID, N-FATTY BETA IMINODIPROPIONIC ACID, AS WELL ASSALTS AND MIXTURES THEREOF.